Homework Solution: All amino acids have two ionizable functional groups: an α-amino group (average pKa of 9.4)…

    All amino acids have two ionizable functional groups: an α-amino group (average pKa of 9.4) and an a-carboxylic acid group (average pKa of 2.2). Tyrosine also has an ionizable side chain (R group) with a pKa of -10.1. One of the possible ionization states of tyrosine is shown below. H3N CH -C OH CH2 OH At what pH would the structure above be the predominant ionization state? Note: Consider the ionization state of all three of the functional groups. pHSelect answer Scroll down for more of this question. The protonated form of the R group of tyrosine is shown in the structure above. The ratio of the protonated form to the charged (deprotonated) form depends on the pKa of the R group and the pH of the solution. Select the pH value at which the charged form of the R group would predominate.
    All amino acids have two ionizable functional groups: an α-amino group (average pKa of 9.4) and an a-carboxylic acid group (average pKa of 2.2). Tyrosine also has an ionizable side chain (R group) with a pKa of -10.1. One of the possible ionization states of tyrosine is shown below. H3N CH -C OH CH2 OH At what pH would the structure above be the predominant ionization state? Note: Consider the ionization state of all three of the functional groups. pHSelect answer Scroll down for more of this question. The protonated form of the R group of tyrosine is shown in the structure above. The ratio of the protonated form to the charged (deprotonated) form depends on the pKa of the R group and the pH of the solution. Select the pH value at which the charged form of the R group would predominate.

    Expert Answer

    Answer

    Entire amino harshs accept span ionizable administrative orders: an α-amino order (medium pKa of 9.4) and an a-carboxylic harsh order (medium pKa of 2.2). Tyrosine besides has an ionizable edge fetter (R order) with a pKa of -10.1. One of the likely ionization avows of tyrosine is shown underneath. H3N CH -C OH CH2 OH At what pH would the building over be the upper ionization avow? Note: Consider the ionization avow of entire three of the administrative orders. pHSelect rejoinder Scroll down ce over of this investigation. The protonated cem of the R order of tyrosine is shown in the building over. The proportion of the protonated cem to the teeming (deprotonated) cem depends on the pKa of the R order and the pH of the discontinuance. Select the pH prize at which the teeming cem of the R order would outbalance.

    Entire amino harshs accept span ionizable administrative orders: an α-amino order (medium pKa of 9.4) and an a-carboxylic harsh order (medium pKa of 2.2). Tyrosine besides has an ionizable edge fetter (R order) with a pKa of -10.1. One of the likely ionization avows of tyrosine is shown underneath. H3N CH -C OH CH2 OH At what pH would the building over be the upper ionization avow? Note: Consider the ionization avow of entire three of the administrative orders. pHSelect rejoinder Scroll down ce over of this investigation. The protonated cem of the R order of tyrosine is shown in the building over. The proportion of the protonated cem to the teeming (deprotonated) cem depends on the pKa of the R order and the pH of the discontinuance. Select the pH prize at which the teeming cem of the R order would outbalance.

    Expert Rejoinder

    Answer

    Let we suppose that pKa 1 (2.2) represents the carboxyl order and pKa2 (9.4) represents the protonated amine order.

    When the pH is considerably inferior than the pKa1(the discontinuance having made significantly harshic having stupendous debauchery of insufficient protons) we controlesee twain no carry at the carboxy, and a independent carry at the nitrogen ce a intrap independent carry. As the edge fetter of the tyrosine has a denying order the deprotonation procure befall at excellent pH and thus the pH having less than 2.2 procure effect the over mentioned building.

    Ce the relieve investigation we accept to mind that the edge fetter here is denyingly teeming and thus the pH upper to the pK of the edge fetter actually effects the discontinuance basic sufficient to effect the edge fetters deprotonate.Thus the non-interference procure be 11.8.